Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 6/20 | 0.33 |
| ▸ | MAOB | P27338 | 6/20 | 0.33 |
| ▸ | AOC2 | O75106 | 5/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 4/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767763 | 0.81 | HRH3 (0.37) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL502587 | 0.81 | MAOA (0.40) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL8405409 | 0.81 | HRH3 (0.37) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL27574307 | 0.81 | HRH3 (0.37) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL2452704 | 0.81 | HRH3 (0.37) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL6723015 | 0.81 | HRH3 (0.53) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL6174120 | 0.77 | HRH3 (0.35) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL4214550 | 0.77 | HRH3 (0.35) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL11451572 | 0.76 | HTT (0.38) | HRH3HPGDTSHR | |
| SCHEMBL5807373 | 0.75 | HRH3 (0.33) | HRH3MAOAMAOBAOC2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B8 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2006093518-A2 | THIENYL COMPOUNDS FOR TREATING VIRUS-RELATED CONDITIONS | APATH, LLC (US) | 2006-09-08 | — | — | WO | disclosed |
| EP-1416933-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgem, Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009847-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM, INC. (US) | 2003-02-06 | — | — | WO | disclosed |
| EP-0065864-B1 | ANTI-HYPERTENSIVE 1-SUBSTITUTED SPIRO (PIPERIDINE-OXOBENZOXAZINES) | SYNTEX (U.S.A.) INC. (US) | 1985-08-28 | — | — | EP | disclosed |
| EP-0065864-A1 | Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazines) | SYNTEX (U.S.A.) INC. (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4349549-A | Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s | SYNTEX (U.S.A.) INC. (US) | 1982-09-14 | — | — | US | disclosed |