Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 6/20 | 0.33 |
| ▸ | MAOB | P27338 | 6/20 | 0.33 |
| ▸ | AOC2 | O75106 | 5/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767763 | 0.81 | HRH3 (0.37) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL2452704 | 0.81 | HRH3 (0.37) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL4675701 | 0.81 | HRH3 (0.40) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL502587 | 0.81 | MAOA (0.40) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL7380988 | 0.81 | HRH3 (0.49) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL4214550 | 0.77 | HRH3 (0.35) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL6174120 | 0.77 | HRH3 (0.35) | HRH3MAOAMAOBAOC2DAO | |
| SCHEMBL11451572 | 0.76 | HTT (0.38) | HRH3 | |
| SCHEMBL9770362 | 0.75 | TDP1 (0.53) | HRH3 | |
| SCHEMBL9463075 | 0.74 | ADRA2A (0.52) | HRH3SIGMAR1HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977106-A | 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives | PIERRE FABRE MEDICAMENT (FR) | 1999-11-02 | — | — | US | claimed |
| EP-0794949-B1 | NOVEL 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES, THEIR PREPARATION AND USE AS DRUGS | PF MEDICAMENT (FR) | 1998-07-29 | — | — | EP | claimed |
| EP-0707571-B1 | 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES AS 5HT1A LIGANDS | PF MEDICAMENT (FR) | 1997-05-02 | — | — | EP | claimed |
| US-5591743-A | ANXIOLYTIC DRUGS OR HYPOTENSIVE AGENTS | PIERRE FABRE MEDICAMENT (FR) | 1997-01-07 | — | — | US | claimed |
| US-5977106-A | 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives | PIERRE FABRE MEDICAMENT (FR) | 1999-11-02 | — | — | US | disclosed |
| US-5977106-A | 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives | PIERRE FABRE MEDICAMENT (FR) | 1999-11-02 | — | — | US | disclosed |
| EP-0794949-B1 | NOVEL 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES, THEIR PREPARATION AND USE AS DRUGS | PF MEDICAMENT (FR) | 1998-07-29 | — | — | EP | disclosed |
| EP-0794949-A1 | NOVEL 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES, THEIR PREPARATION AND USE AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-09-17 | — | — | EP | disclosed |
| US-5591743-A | ANXIOLYTIC DRUGS OR HYPOTENSIVE AGENTS | PIERRE FABRE MEDICAMENT (FR) | 1997-01-07 | — | — | US | disclosed |
| WO-1996016949-A1 | NOVEL 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES, THEIR PREPARATION AND USE AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1996-06-06 | — | — | WO | disclosed |