Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.40 |
| ▸ | MAOB | P27338 | 6/20 | 0.40 |
| ▸ | AOC2 | O75106 | 5/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405409 | 0.81 | HRH3 (0.37) | MAOAMAOBAOC2DAOHRH3 | |
| SCHEMBL3767763 | 0.81 | HRH3 (0.37) | MAOAMAOBAOC2DAOHRH3 | |
| SCHEMBL2452704 | 0.81 | HRH3 (0.37) | MAOAMAOBAOC2DAOHRH3 | |
| SCHEMBL4675701 | 0.81 | HRH3 (0.40) | MAOAMAOBAOC2DAOHTR2A | |
| SCHEMBL27574307 | 0.81 | HRH3 (0.37) | MAOAMAOBAOC2DAOHTR2A | |
| SCHEMBL718265 | 0.81 | HRH3 (0.49) | MAOAMAOBAOC2DAOHTR2A | |
| SCHEMBL29841223 | 0.81 | HRH3 (0.49) | MAOAMAOBAOC2DAOHTR2A | |
| Hydrochloric Acid SCHEMBL15825664 | 0.79 | AOC2 (0.51) | MAOAMAOBAOC2DAOHTR2A | |
| SCHEMBL6174120 | 0.77 | HRH3 (0.35) | MAOAMAOBAOC2DAOHRH3 | |
| SCHEMBL4214550 | 0.77 | HRH3 (0.35) | MAOAMAOBAOC2DAOHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271634-B1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | INTEGRATIVE RES LAB SWEDEN AB (SE) | 2014-02-12 | — | — | EP | disclosed |
| US-8524766-B2 | Modulators of dopamine neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2013-09-03 | — | — | US | disclosed |
| US-20120088792-A1 | Pyridin-2-YL Methylamine Derivatives for Treating Opiate Dependence | PIERRE FABRE MEDICAMENT (FR) | 2012-04-12 | — | — | US | disclosed |
| US-8106074-B2 | Pyridin-2-yl-methylamine derivatives for treating opiate dependence | PIERRE FABRE MEDICAMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-20110105461-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-05-05 | — | — | US | disclosed |
| EP-2271634-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, Filial af NeuroSearch Sweden AB, Sverige (DK) | 2011-01-12 | — | — | EP | disclosed |
| US-20100099709-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES FOR TREATING OPIATE DEPENDENCE | PIERRE FABRE MEDICAMENT (FR) | 2010-04-22 | — | — | US | disclosed |
| WO-2009133107-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2009-11-05 | — | — | WO | disclosed |
| US-7488751-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| US-5496847-A | ANXIOLYTIC AND ANTIDEPRESSANT | BRISTOL-MYERS SQUIBB CO. (US) | 1996-03-05 | — | — | US | disclosed |
| US-5391570-A | Anxiolytic agents; antidepressants | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |
| US-5391570-A | Anxiolytic agents; antidepressants | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |
| US-5391570-A | Anxiolytic agents; antidepressants | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5245051-A | Antipsychotic chroman derivatives of benzodioxanmethylamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-09-14 | — | — | US | disclosed |
| US-5235055-A | Antipsychotic quinoline derivatives of benzodioxanmethylamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-10 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | TPH1, TPH2, HTR2C | MAOA 60/4885MAOB 57/4885AOC2 1518/4885 |
| US-20110105461-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | DBH, SLC18A2, SLC6A3 | MAOA 74/4885MAOB 95/4885AOC2 561/4885 |
| US-20120088792-A1 | Pyridin-2-YL Methylamine Derivatives for Treating Opiate Dependence | OPRK1, OPRM1, OPRD1 | MAOA 350/4885MAOB 236/4885AOC2 3666/4885 |
| US-20100099709-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES FOR TREATING OPIATE DEPENDENCE | OPRM1, OPRK1, OPRD1 | MAOA 452/4885MAOB 395/4885AOC2 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.