SCHEMBL4675894

SCHEMBL4675894

COCCOC(=O)[C](C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.43
THRB P10828 1/20 0.40
ALDH1A1 P00352 7/20 0.36
LMNA P02545 2/20 0.35
KDM4E B2RXH2 1/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
CHRM5 P08912 2/20 0.34
CHRM1 P11229 2/20 0.34
CHRM3 P20309 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
HSD17B10 Q99714 1/20 0.32
GAA P10253 1/20 0.32
RAB9A P51151 1/20 0.32
PGR P06401 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
HTR1A P08908 1/20 0.31
CHRNB2 P17787 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27859554 0.86 TSHR (0.48) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL3012356 0.84 TSHR (0.43) TSHRTHRBALDH1A1LMNAKDM4E
Ammonia Solution, Strong SCHEMBL27753009 0.82 TSHR (0.42) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL21796075 0.80 TSHR (0.41) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL860176 0.80 TSHR (0.41) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL27357 0.80 THRB (0.63) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL8970903 0.80 TSHR (0.41) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL14155764 0.79 THRB (0.45) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL22587297 0.79 THRB (0.45) TSHRTHRBALDH1A1LMNAKDM4E
SCHEMBL16170327 0.78 TSHR (0.39) TSHRTHRBALDH1A1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1095935-B1 6-Hydroxy-5,6-dihydrouracils as herbicides SUMITOMO CHEMICAL CO (JP) 2008-12-17 EP disclosed
EP-1101761-B1 Process for producing 3-phenyluracil compounds SUMITOMO CHEMICAL CO (JP) 2005-08-17 EP disclosed
US-6410484-B1 ACTIVE MATERIAL; CONTROLLING WEEDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-06-25 US disclosed
US-6339155-B1 Process for producing 3-phenyluracil compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-15 US disclosed
EP-1101761-A2 Process for producing 3-phenyluracil compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-05-23 EP disclosed
EP-1095935-A1 6-Hydroxy-5,6-dihydrouracils as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-05-02 EP disclosed
US-4398913-A ALKALINE PASTES CASSELLA AKTIENGESELLSCHAFT (DE) 1983-08-16 US disclosed