Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 4/20 | 0.65 |
| ▸ | PRKCB | P05771 | 2/20 | 0.62 |
| ▸ | PRKCA | P17252 | 2/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.62 |
| ▸ | PRKCH | P24723 | 1/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | PRKACG | P22612 | 1/20 | 0.58 |
| ▸ | PRKACB | P22694 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679424 | 0.89 | CAMK2D (0.80) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL2945607 | 0.88 | PRKCA (0.81) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL4680242 | 0.86 | PRKCA (0.72) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL4680373 | 0.86 | GSK3B (0.60) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL4352410 | 0.85 | GSK3B (0.67) | CAMK2DPRKCBPRKCAGSK3BIDH1 | |
| SCHEMBL6192685 | 0.85 | CAMK2D (0.57) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL4681657 | 0.85 | CAMK2D (0.58) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL4680012 | 0.84 | PRKCA (0.61) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL4676092 | 0.84 | GSK3B (0.58) | CAMK2DPRKCBPRKCAPRKCEPRKCH | |
| SCHEMBL13166896 | 0.83 | PRKCA (0.65) | CAMK2DPRKCBPRKCAPRKCEPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513520-B1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |
| EP-1513520-A2 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003103663-A2 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-18 | — | — | WO | disclosed |