Helicide

Helicide

SCHEMBL467669

O=Cc1ccc(OC2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TYR P14679 1/20 0.69
KDM4E B2RXH2 1/20 0.58
POLB P06746 1/20 0.58
GAA P10253 1/20 0.58
MAPT P10636 1/20 0.58
G6PD P11413 1/20 0.58
MAPK1 P28482 1/20 0.58
ADRA1A P35348 1/20 0.58
PTGS2 P35354 1/20 0.58
AKR1B1 P15121 1/20 0.57
DPP4 P27487 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Helicide SCHEMBL23457333 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL5030879 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL17822698 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL9426962 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL987981 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
SCHEMBL6842994 0.99 TYR (0.67) TYRKDM4EPOLBGAAMAPT
SCHEMBL6842995 0.99 TYR (0.67) TYRKDM4EPOLBGAAMAPT
SCHEMBL9189048 0.88 KDM4E (0.59) TYRKDM4EPOLBGAAMAPT
SCHEMBL16785945 0.88 TYR (0.87) TYRKDM4EPOLBGAAMAPT
SCHEMBL17366540 0.88 TYR (0.87) TYRKDM4EPOLBGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112724185-A Preparation method of gastrodin impurity 北京悦康科创医药科技股份有限公司 2021-04-30 CN claimed
CN-115554256-B Preparation method and quality control method of gastrodin tablet 乐泰药业有限公司 2024-04-02 CN disclosed
CN-115554256-A Preparation method and quality control method of gastrodin tablets 乐泰药业有限公司 2023-01-03 CN disclosed
CN-104769121-B Vanillin synthase 埃沃尔瓦公司 2021-06-01 CN disclosed
CN-112724185-A Preparation method of gastrodin impurity 北京悦康科创医药科技股份有限公司 2021-04-30 CN disclosed
CN-112724185-A Preparation method of gastrodin impurity 北京悦康科创医药科技股份有限公司 2021-04-30 CN disclosed
US-10689672-B2 Vanillin synthase EVOLVA SA (CH) 2020-06-23 US disclosed
EP-3665180-A1 COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS IN ANAEROBIC CELLS AND RELATED CLINICAL METHODS FOR TREATING CANCER AND PATHOGENIC INFECTIONS Cognate 3 LLC (US) 2020-06-17 EP disclosed
WO-2019032411-A1 COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS IN ANAEROBIC CELLS AND RELATED CLINICAL METHODS FOR TREATING CANCER AND PATHOGENIC INFECTIONS COGNATE 3 LLC (US) 2019-02-14 WO disclosed
US-20150267227-A1 Vanillin Synthase DANSTAR FERMENT AG (CH) 2015-09-24 US disclosed
US-20110318793-A1 Method of Producing a Low Molecular Weight Organic Compound in a Cell EVOLVA SA (CH) 2011-12-29 US disclosed
EP-2388333-A2 A method of producing a low molecular weight organic compound in a cell Evolva SA (CH) 2011-11-23 EP disclosed
US-8041750-B2 Method and apparatus for organizing and playing data YAHOO! INC. (US) 2011-10-18 US disclosed
US-20110136177-A1 Method of Producing a Low Molecular Weight Organic Compound in a Cell BLMaps (DK) 2011-06-09 US disclosed
US-7846697-B2 Method of producing a low molecular weight organic compound in a cell BLMaps (DK) 2010-12-07 US disclosed
US-7700701-B2 Water-soluble polymer compound having sugar chains TOYO BOSEKI KABUSHIKI KAISHA (JP) 2010-04-20 US disclosed
US-20060287457-A1 Sugar chain-containing water-soluble polymer compound NISHIMURA, SHIN-ICHIRO, MR. (JP) 2006-12-21 US disclosed
US-20060275877-A1 Method of producing a low molecular weight organic compound in a cell DANSTAR FERMENT AG (CH) 2006-12-07 US disclosed
EP-1649029-A1 A METHOD OF PRODUCING A LOW MOLECULAR WEIGHT ORGANIC COMPOUND IN A CELL Poalis A/S (DK) 2006-04-26 EP disclosed
WO-2004111254-A1 A METHOD OF PRODUCING A LOW MOLECULAR WEIGHT ORGANIC COMPOUND IN A CELL POALIS A/S (DK) 2004-12-23 WO disclosed