Helicide

Helicide

SCHEMBL5030879

O=Cc1ccc(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TYR P14679 1/20 0.69
KDM4E B2RXH2 1/20 0.58
POLB P06746 1/20 0.58
GAA P10253 1/20 0.58
MAPT P10636 1/20 0.58
G6PD P11413 1/20 0.58
MAPK1 P28482 1/20 0.58
ADRA1A P35348 1/20 0.58
PTGS2 P35354 1/20 0.58
AKR1B1 P15121 1/20 0.57
DPP4 P27487 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Helicide SCHEMBL23457333 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL17822698 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL467669 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL9426962 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL987981 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
SCHEMBL6842994 0.99 TYR (0.67) TYRKDM4EPOLBGAAMAPT
SCHEMBL6842995 0.99 TYR (0.67) TYRKDM4EPOLBGAAMAPT
SCHEMBL9189048 0.88 KDM4E (0.59) TYRKDM4EPOLBGAAMAPT
SCHEMBL16785945 0.88 TYR (0.87) TYRKDM4EPOLBGAAMAPT
SCHEMBL17366540 0.88 TYR (0.87) TYRKDM4EPOLBGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080220140-A1 USE OF PROPENYLPHENYL GLYCOSIDES FOR ENHANCING SWEET SENSORY IMPRESSIONS SYMRISE GMBH & CO. KG (DE) 2008-09-11 US disclosed
EP-1955601-A1 Use of propenylphenylglycosides for intensifying sweet sensory impressions Symrise GmbH & Co. KG (DE) 2008-08-13 EP disclosed