Helicide

Helicide

SCHEMBL987981

O=Cc1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TYR P14679 1/20 0.69
KDM4E B2RXH2 1/20 0.58
POLB P06746 1/20 0.58
GAA P10253 1/20 0.58
MAPT P10636 1/20 0.58
G6PD P11413 1/20 0.58
MAPK1 P28482 1/20 0.58
ADRA1A P35348 1/20 0.58
PTGS2 P35354 1/20 0.58
AKR1B1 P15121 1/20 0.57
DPP4 P27487 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Helicide SCHEMBL23457333 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL5030879 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL17822698 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL467669 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
Helicide SCHEMBL9426962 1.00 TYR (0.69) TYRKDM4EPOLBGAAMAPT
SCHEMBL6842994 0.99 TYR (0.67) TYRKDM4EPOLBGAAMAPT
SCHEMBL6842995 0.99 TYR (0.67) TYRKDM4EPOLBGAAMAPT
SCHEMBL9189048 0.88 KDM4E (0.59) TYRKDM4EPOLBGAAMAPT
SCHEMBL16785945 0.88 TYR (0.87) TYRKDM4EPOLBGAAMAPT
SCHEMBL17366540 0.88 TYR (0.87) TYRKDM4EPOLBGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152614-A1 Compositions And Methods For Inducing Apoptosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ROBERTS SUZANNAH JANE (US) 2025-05-15 US claimed
US-20240316087-A1 Compositions And Methods For Inducing Apoptosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ROBERTS SUZANNAH JANE (US) 2024-09-26 US claimed
US-20240050458-A1 Compositions And Methods For Inducing Apopotosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ROBERTS SUZANNAH JANE (US) 2024-02-15 US claimed
US-20200360408-A1 Compositions And Methods For Inducing Apoptosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections COGNATE 3 LLC 2020-11-19 US claimed
US-20200253998-A1 Compositions And Methods For Immunotherapy BROWN JOE ERNEST (US) 2020-08-13 US claimed
US-20160113955-A1 Compositions And Methods For Immunotherapy BROWN JOE ERNEST (US) 2016-04-28 US claimed
US-20160008388-A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY BROWN JOE ERNEST (US) 2016-01-14 US claimed
US-20120251490-A1 Compositions And Methods For Immunotherapy BROWN JOE ERNEST (US) 2012-10-04 US claimed
US-20110311478-A1 Combinatorial Methods For Treating Cellular Proliferative Disorders And Immune Deficiencies Using Salicinium BROWN JOE ERNEST (US) 2011-12-22 US claimed
US-20110311477-A1 Infusion Treatment Methods And Compositions Using Salicinium For Treating Cellular Proliferative Disorders And Immune Deficiencies BROWN JOE ERNEST (US) 2011-12-22 US claimed
US-20110311476-A1 Methods For Treating An Immune Deficiency Or Enhancing Immune Function Using Salicinium, Non-Limited In Terms Of Treatment Indication, But Encompassing Methods For Treating Cancer And Microbial, Bacterial, Viral, Fungal; Non-Limited In Terms of Delivery Mode, Formulation BROWN JOE ERNEST (US) 2011-12-22 US claimed
EP-2271350-A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY Cognate3, LLC. (US) 2011-01-12 EP claimed
WO-2009145841-A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY COGNATE 3, LLC (US) 2009-12-03 WO claimed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
US-20250213685-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES ABBVIE INC (US) 2025-07-03 US disclosed
US-20250177374-A1 BCL-XL Inhibitory Compounds Having Low Cell Permeability and Antibody Drug Conjugates Including the Same ABBVIE INC (US) 2025-06-05 US disclosed
EP-2271350-A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY Cognate3, LLC. (US) 2011-01-12 EP disclosed
WO-2009145841-A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY COGNATE 3, LLC (US) 2009-12-03 WO disclosed
US-20090281047-A1 Compositions And Methods For Immunotherapy COGNATE3 LLC 2009-11-12 US disclosed
EP-0455432-B1 Alpha-glycosyl naringin, and its preparation and uses HAYASHIBARA BIOCHEM LAB (JP) 1996-03-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160008388-A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY ICOS, IL2, NFATC1 TYR 553/4885KDM4E 2739/4885POLB 638/4885
US-20090281047-A1 Compositions And Methods For Immunotherapy ICOS, IL2, NFATC1 TYR 553/4885KDM4E 2739/4885POLB 638/4885
US-20240050458-A1 Compositions And Methods For Inducing Apopotosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ENGASE, AGL, GAA TYR 877/4885KDM4E 2840/4885POLB 992/4885
US-20250213685-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES EGFR, ERBB2, ERBB3 TYR 3490/4885KDM4E 1013/4885POLB 3852/4885
US-20110311478-A1 Combinatorial Methods For Treating Cellular Proliferative Disorders And Immune Deficiencies Using Salicinium NFATC1, MKI67, MYD88 TYR 1389/4885KDM4E 3095/4885POLB 539/4885
US-20110311477-A1 Infusion Treatment Methods And Compositions Using Salicinium For Treating Cellular Proliferative Disorders And Immune Deficiencies IDO1, MKI67, ADSL TYR 1401/4885KDM4E 3215/4885POLB 532/4885
US-20110311476-A1 Methods For Treating An Immune Deficiency Or Enhancing Immune Function Using Salicinium, Non-Limited In Terms Of Treatment Indication, But Encompassing Methods For Treating Cancer And Microbial, Bacterial, Viral, Fungal; Non-Limited In Terms of Delivery Mode, Formulation IDO1, TLR5, IDO2 TYR 937/4885KDM4E 1411/4885POLB 1318/4885
US-20240316087-A1 Compositions And Methods For Inducing Apoptosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ENGASE, AGL, GAA TYR 2234/4885KDM4E 1749/4885POLB 966/4885
US-20120251490-A1 Compositions And Methods For Immunotherapy ICOS, IL2, NFATC1 TYR 553/4885KDM4E 2739/4885POLB 638/4885
US-20200360408-A1 Compositions And Methods For Inducing Apoptosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ENGASE, AGL, GAA TYR 2234/4885KDM4E 1749/4885POLB 966/4885
US-20200253998-A1 Compositions And Methods For Immunotherapy ICOS, NFATC1, IL2 TYR 630/4885KDM4E 3257/4885POLB 774/4885
US-20160113955-A1 Compositions And Methods For Immunotherapy ICOS, IL2, NFATC1 TYR 553/4885KDM4E 2739/4885POLB 638/4885
US-20250152614-A1 Compositions And Methods For Inducing Apoptosis In Anaerobic Cells And Related Clinical Methods For Treating Cancer And Pathogenic Infections ENGASE, AGL, GAA TYR 2234/4885KDM4E 1749/4885POLB 966/4885
US-20250177374-A1 BCL-XL Inhibitory Compounds Having Low Cell Permeability and Antibody Drug Conjugates Including the Same BCL2, BAX, BCL9 TYR 4528/4885KDM4E 1299/4885POLB 4027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.