Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.50 |
| ▸ | PRKCA | P17252 | 3/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 5/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679997 | 0.91 | GSK3B (0.51) | GSK3BPRKCAPRKCGPRKCBCAMK2D | |
| SCHEMBL2946233 | 0.88 | PRKCA (0.51) | GSK3BPRKCAPRKCGPRKCBCAMK2D | |
| SCHEMBL4680124 | 0.83 | PRKCA (0.47) | GSK3BPRKCAPRKCGPRKCBCAMK2D | |
| SCHEMBL4684125 | 0.83 | PRKCA (0.62) | GSK3BPRKCAPRKCGPRKCBCAMK2D | |
| SCHEMBL5756702 | 0.77 | GSK3B (0.71) | GSK3BPRKCAPRKCGPRKCBCAMK2D | |
| SCHEMBL7522211 | 0.77 | CCNE2 (0.65) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL3775971 | 0.72 | GSK3B (0.61) | GSK3BPRKCAPRKCGPRKCBPRKACA | |
| SCHEMBL4683218 | 0.71 | GSK3B (0.55) | GSK3BPRKCAPRKCBQPCTPRKACA | |
| SCHEMBL4683103 | 0.70 | PRKCA (0.64) | GSK3BPRKCAPRKCGPRKCBQPCT | |
| SCHEMBL7529358 | 0.67 | GSK3B (0.72) | GSK3BPRKCACCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513520-B1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |