Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.71 |
| ▸ | PRKCG | P05129 | 10/20 | 0.71 |
| ▸ | PRKCB | P05771 | 10/20 | 0.71 |
| ▸ | PRKCA | P17252 | 10/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | MYLK | Q15746 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775971 | 0.92 | GSK3B (0.61) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5755763 | 0.89 | GSK3B (0.64) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5757611 | 0.87 | GSK3B (0.59) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5758306 | 0.83 | GSK3B (1.00) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5758314 | 0.81 | CAMK2D (0.62) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL3777462 | 0.80 | GSK3B (0.53) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL2946233 | 0.79 | PRKCA (0.51) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL4676750 | 0.77 | GSK3B (0.50) | GSK3BPRKCGPRKCBPRKCAPRKACA | |
| SCHEMBL7090205 | 0.76 | GSK3B (0.42) | GSK3BPRKCGPRKCBPRKCAMYLK | |
| SCHEMBL5758532 | 0.76 | PRKCA (0.84) | GSK3BPRKCGPRKCBPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |