Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678438 | 0.87 | ACHE (0.63) | ACHEEPHX1L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL2781381 | 0.86 | MEN1 (0.68) | ACHEEPHX1L3MBTL3L3MBTL1POLB | |
| SCHEMBL7809522 | 0.84 | ACHE (0.64) | ACHEEPHX1L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL4283757 | 0.82 | ACHE (0.56) | ACHEEPHX1L3MBTL3L3MBTL1MEN1 | |
| SCHEMBL27748883 | 0.81 | ACHE (0.68) | ACHEEPHX1L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL4156411 | 0.80 | ACHE (0.58) | ACHEEPHX1L3MBTL3L3MBTL1MEN1 | |
| SCHEMBL11616794 | 0.80 | ACHE (0.71) | ACHEEPHX1L3MBTL3L3MBTL1MEN1 | |
| SCHEMBL14597201 | 0.79 | ACHE (0.61) | ACHEEPHX1L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL7129676 | 0.79 | HPGD (0.79) | ACHEL3MBTL1KDM4EALDH1A1POLB | |
| SCHEMBL252026 | 0.79 | HPGD (0.79) | ACHEL3MBTL1KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485363-B1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2008-10-08 | — | — | EP | disclosed |
| EP-1485363-A1 | CYCLIC AMIDES | MERCK PATENT GmbH (DE) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003076420-A1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2003-09-18 | — | — | WO | disclosed |