Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25772130 | 0.90 | ACHE (0.59) | ACHEKMT2AMEN1HPGDLMNA | |
| SCHEMBL28355752 | 0.89 | HPGD (0.56) | ACHEKMT2AMEN1HPGDLMNA | |
| SCHEMBL31003116 | 0.85 | HSD11B1 (0.57) | ACHEKMT2AMEN1HPGDLMNA | |
| SCHEMBL10196662 | 0.85 | KMT2A (0.65) | KMT2AMEN1HPGDLMNAL3MBTL3 | |
| SCHEMBL744630 | 0.84 | LMNA (0.49) | ACHEKMT2AMEN1HPGDLMNA | |
| SCHEMBL19915895 | 0.84 | MGLL (0.56) | ACHEKMT2AMEN1HPGDLMNA | |
| SCHEMBL28355937 | 0.84 | EPHX1 (0.54) | KMT2AMEN1HPGDLMNAEPHX1 | |
| SCHEMBL95384 | 0.84 | HPGD (0.52) | ACHEKMT2AMEN1HPGDLMNA | |
| SCHEMBL7809522 | 0.84 | ACHE (0.64) | ACHEKMT2AMEN1HPGDEPHX1 | |
| SCHEMBL4678438 | 0.83 | ACHE (0.63) | ACHEKMT2AMEN1HPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360737-A | 2-amino-5-piperidinylimidazolone compounds and their use for beta secretase modulation | WYETH CORP (US) | 2009-02-04 | — | — | CN | disclosed |