Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 7/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677237 | 0.83 | SLC6A4 (0.50) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| SCHEMBL18324829 | 0.77 | DRD2 (0.61) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| SCHEMBL4672945 | 0.76 | OPRM1 (0.64) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| Bromide SCHEMBL7870891 | 0.75 | DRD2 (0.73) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL7867314 | 0.75 | DRD2 (0.73) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| SCHEMBL4671289 | 0.74 | SLC6A4 (0.52) | DRD2SLC6A4HTR2AOPRM1OPRL1 | |
| SCHEMBL18324890 | 0.74 | DRD2 (0.63) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| SCHEMBL16802074 | 0.74 | KDM4E (0.69) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| SCHEMBL18324826 | 0.72 | DRD2 (0.61) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| SCHEMBL6184605 | 0.72 | DRD2 (0.61) | DRD2SLC6A4ADRA1DHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |