Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.64 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 7/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672939 | 0.81 | OPRM1 (0.50) | OPRM1OPRL1OPRK1DRD2SLC6A4 | |
| SCHEMBL8299251 | 0.79 | DRD2 (0.73) | OPRM1OPRL1OPRK1DRD2SLC6A4 | |
| SCHEMBL14280674 | 0.78 | OPRL1 (1.00) | OPRM1OPRL1OPRK1DRD2SLC6A4 | |
| SCHEMBL8878693 | 0.77 | SLC6A4 (0.78) | OPRM1OPRL1OPRK1DRD2SLC6A4 | |
| Bromide SCHEMBL7870891 | 0.76 | DRD2 (0.73) | OPRM1OPRL1DRD2SLC6A4ADRA1D | |
| Hydrochloric Acid SCHEMBL7867314 | 0.76 | DRD2 (0.73) | OPRM1OPRL1DRD2SLC6A4ADRA1D | |
| SCHEMBL18324859 | 0.76 | DRD2 (0.58) | OPRM1OPRL1OPRK1DRD2SLC6A4 | |
| SCHEMBL4677243 | 0.76 | DRD2 (0.55) | OPRM1OPRL1DRD2SLC6A4ADRA1D | |
| SCHEMBL8877539 | 0.75 | ADRA1D (0.79) | DRD2SLC6A4ADRA1DHTR2AHTR1A | |
| SCHEMBL30877204 | 0.75 | DRD2 (0.67) | OPRM1OPRL1DRD2SLC6A4ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |