Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 8/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677317 | 1.00 | ADAMTS4 (0.49) | ADAMTS4MMP13SMN1; SMN2NAMPTALDH1A1 | |
| SCHEMBL4674652 | 0.83 | ADAMTS4 (0.61) | ADAMTS4MMP13 | |
| SCHEMBL4671219 | 0.74 | ADAM17 (0.51) | ADAMTS4MMP13MAPT | |
| SCHEMBL4671221 | 0.74 | ADAM17 (0.51) | ADAMTS4MMP13MAPT | |
| SCHEMBL13409570 | 0.74 | MAPT (0.50) | ADAMTS4MMP13SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2385780 | 0.71 | GPR119 (0.67) | SMN1; SMN2 | |
| SCHEMBL4674790 | 0.70 | ADAMTS4 (0.49) | ADAMTS4MMP13ALDH1A1GFERMAPT | |
| SCHEMBL4674788 | 0.70 | ADAMTS4 (0.49) | ADAMTS4MMP13ALDH1A1GFERMAPT | |
| SCHEMBL4676848 | 0.70 | MAPT (0.49) | ADAMTS4MMP13ALDH1A1MAPT | |
| SCHEMBL4676843 | 0.70 | MAPT (0.49) | ADAMTS4MMP13ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |