Fumaric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ACE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ATP4A ATP4B AXL BTK CACNA1C CACNA1D CACNA1F CACNA1S CCR5 CHRM2 CHRM3 CPT1B CPT2 DPP4 DRD1 DRD2 EGFR ERBB2 ERBB4 FLT3 HRH1 HRH3 HTR1A HTR2A HTR2B HTR2C HTR4 JAK1 JAK2 JAK3 KCNH2 KMT2A MAP2K1 MAP2K2 MEN1 MLNR MPL MTOR P PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLK4 PPARG REN S1PR1 SLC6A2 SLC6A3 SLC6A4 SMO TYK2 atpA atpB atpC atpD atpE atpF atpFH atpG pol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	HTR2C known ✓	P28335	2/20	0.55

▸	HTR2A known ✓	P28223	2/20	0.33

▸	SLC6A2 known ✓	P23975	1/20	0.31

▸	SLC6A4 known ✓	P31645	1/20	0.31

▸	SLC6A3 known ✓	Q01959	1/20	0.31

▸	CPS1	P31327	1/20	0.39

▸	EPHX2	P34913	1/20	0.36

▸	FFAR4	Q5NUL3	7/20	0.33

▸	GCK	P35557	1/20	0.32

▸	ESR1	P03372	2/20	0.32

▸	NPC1	O15118	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fumaric Acid SCHEMBL4678304	1.00	HTR2C (0.55)	HTR2CCPS1EPHX2FFAR4HTR2A
SCHEMBL4680849	0.94	HTR2C (0.61)	HTR2CCPS1EPHX2FFAR4HTR2A
SCHEMBL4680854	0.94	HTR2C (0.61)	HTR2CCPS1EPHX2FFAR4HTR2A
SCHEMBL906036	0.85	HTR2C (0.61)	HTR2CCPS1EPHX2
SCHEMBL4680495	0.85	HTR2C (0.61)	HTR2CCPS1EPHX2
Fumaric Acid SCHEMBL4678307	0.85	HTR2C (0.59)	HTR2CCPS1HTR2ANPC1
Hydrochloric Acid SCHEMBL4678445	0.84	HTR2C (0.60)	HTR2CCPS1EPHX2
Hydrochloric Acid SCHEMBL4678449	0.84	HTR2C (0.60)	HTR2CCPS1EPHX2
Fumaric Acid SCHEMBL4681179	0.80	HTR2C (0.59)	HTR2C
Fumaric Acid SCHEMBL4681183	0.80	HTR2C (0.59)	HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1343775-B1	PIPERAZINE DERIVATIVES	HOFFMANN LA ROCHE (CH)	2008-06-04	—	—	EP	disclosed
US-7022707-B2	Piperazine derivatives	HOFFMAN-LA ROCHE INC. (US)	2006-04-04	—	—	US	disclosed
US-20040235859-A1	Novel piperazine derivatives	ADAMS DAVID REGINALD (GB)	2004-11-25	—	—	US	disclosed
EP-1343775-A2	PIPERAZINE DERIVATIVES	F. HOFFMANN-LA ROCHE AG (CH)	2003-09-17	—	—	EP	disclosed
US-20020143020-A1	Novel piperazine derivatives	VERNALIS RESEARCH LIMITED (GB)	2002-10-03	—	—	US	disclosed
WO-2002048124-A2	PIPERAZINE DERIVATIVES	F. HOFFMANN-LA ROCHE AG (CH)	2002-06-20	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20020143020-A1	Novel piperazine derivatives	CYP4B1, UGT1A1, CYP1B1	HTR2C 289/4885HTR2A 443/4885SLC6A2 3003/4885
US-20040235859-A1	Novel piperazine derivatives	CYP4B1, UGT1A1, CYP1B1	HTR2C 289/4885HTR2A 443/4885SLC6A2 3003/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.