Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 10/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.35 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467949 | 0.91 | EML4 (0.42) | — | |
| SCHEMBL467659 | 0.86 | AXL (0.49) | L3MBTL3L3MBTL1ALDH1A1MAPTAXL | |
| SCHEMBL28039190 | 0.84 | L3MBTL3 (0.42) | L3MBTL3L3MBTL1GAAMAPTAXL | |
| SCHEMBL467833 | 0.84 | AXL (0.47) | L3MBTL3L3MBTL1ALDH1A1AXLMBTD1 | |
| SCHEMBL467609 | 0.84 | NOTUM (0.42) | L3MBTL3L3MBTL1AXLMBTD1HRH3 | |
| SCHEMBL28823415 | 0.83 | L3MBTL3 (0.61) | L3MBTL3L3MBTL1MBTD1HRH3TP53BP1 | |
| SCHEMBL467946 | 0.82 | HRH3 (0.40) | L3MBTL3L3MBTL1MBTD1HRH3 | |
| SCHEMBL467792 | 0.80 | AXL (0.44) | L3MBTL3L3MBTL1AXLMBTD1HRH3 | |
| SCHEMBL467696 | 0.79 | AXL (0.43) | L3MBTL1ALDH1A1AXL | |
| SCHEMBL467478 | 0.79 | AXL (0.42) | ALDH1A1GAAMAPTMEN1NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |