Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250885 | 0.82 | CES1 (0.53) | ALDH1A1TDP1CES1MEN1KMT2A | |
| SCHEMBL335254 | 0.81 | MEN1 (0.50) | FDPSMAPTALDH1A1GFERCYP3A4 | |
| SCHEMBL28614083 | 0.79 | HDAC3 (0.37) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL10338250 | 0.74 | MEN1 (0.46) | ALDH1A1TDP1CES1MEN1KMT2A | |
| SCHEMBL7306368 | 0.74 | GFER (0.44) | FDPSMAPTALDH1A1GFERCYP3A4 | |
| SCHEMBL6968790 | 0.73 | KDM4E (0.47) | MAPTALDH1A1TSHRTDP1MAOB | |
| SCHEMBL24193442 | 0.72 | MEN1 (0.47) | ALDH1A1TDP1CES1MEN1KMT2A | |
| SCHEMBL14269830 | 0.71 | RIPK1 (0.50) | MAPTALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL5007989 | 0.71 | MEN1 (0.44) | ALDH1A1TDP1CES1MEN1KMT2A | |
| SCHEMBL4806015 | 0.71 | RAB9A (0.50) | MAPTALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957460-A1 | BICYCLIC COMPOUNDS WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007067444-A1 | BICYCLIC COMPOUNDS WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |