Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4684017 | 0.77 | KCNJ11 (0.42) | KCNJ11 | |
| SCHEMBL4683462 | 0.77 | KCNQ3 (0.45) | KCNJ11 | |
| SCHEMBL9954855 | 0.76 | KMT2A (0.56) | KDM4ERAB9AALDH1A1NPC1LMNA | |
| SCHEMBL11227303 | 0.76 | NPC1 (0.50) | KDM4ERAB9AALDH1A1NPC1HTT | |
| SCHEMBL8032376 | 0.76 | KMT2A (0.56) | KDM4ERAB9AALDH1A1NPC1LMNA | |
| SCHEMBL6954710 | 0.75 | KMT2A (0.49) | KDM4ERAB9AALDH1A1NPC1LMNA | |
| SCHEMBL8854243 | 0.75 | ABCC9 (0.40) | KDM4ERAB9AALDH1A1LMNAHTT | |
| SCHEMBL4683576 | 0.73 | KCNJ11 (0.45) | KCNJ11 | |
| SCHEMBL4678738 | 0.72 | KMT2A (0.49) | KDM4ERAB9AALDH1A1NPC1LMNA | |
| SCHEMBL4678743 | 0.72 | KMT2A (0.49) | KDM4ERAB9AALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |