Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787406 | 0.97 | MAPT (0.59) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL4676500 | 0.94 | MAPT (0.63) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL4844039 | 0.85 | MAPT (0.63) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL8483054 | 0.84 | MAPT (0.67) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL4675271 | 0.84 | CYP2C8 (0.59) | MAPTRAB9ALMNAMAPK1NPC1 | |
| SCHEMBL24149128 | 0.83 | MAPT (0.65) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL4841745 | 0.83 | NPC1 (0.58) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL2870865 | 0.83 | MAPT (0.65) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL16108714 | 0.82 | AKR1C3 (0.43) | MAPTNPSR1KMT2ARAB9ALMNA | |
| SCHEMBL181455 | 0.82 | MAPT (0.63) | MAPTNPSR1KMT2ARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666495-A | Potassium channel modulators | ABBOTT LAB | 2012-09-12 | — | — | CN | disclosed |
| EP-1572672-B1 | BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS | SOSEI R & D LTD (GB) | 2008-08-13 | — | — | EP | disclosed |
| EP-1950206-A1 | Benzoxazocines and their use as monoamine-reuptake inhibitors | Sosei R&D Ltd. (GB) | 2008-07-30 | — | — | EP | disclosed |
| US-20060019940-A1 | Novel benzoxazocines and their therapeutic use | SOSEI R&D LTD. (GB) | 2006-01-26 | — | — | US | disclosed |
| EP-1572672-A1 | BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS | Arakis Ltd. (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056788-A1 | BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS | ARAKIS LTD. (GB) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019940-A1 | Novel benzoxazocines and their therapeutic use | HTR4, OPRM1, GRM4 | MAPT 3319/4885NPSR1 63/4885KMT2A 1143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.