Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680433 | 0.94 | CYP2C8 (0.59) | CYP2C8CES2CES1LMNAALDH1A1 | |
| SCHEMBL7822107 | 0.88 | CYP2C8 (0.64) | CYP2C8CES2CES1LMNAALDH1A1 | |
| SCHEMBL25223545 | 0.84 | MAPT (0.63) | CYP2C8CES2CES1LMNAHPGD | |
| SCHEMBL25653103 | 0.84 | CES2 (0.53) | CYP2C8CES2CES1LMNAALDH1A1 | |
| SCHEMBL4679518 | 0.84 | MAPT (0.63) | LMNAALDH1A1CYP1A2PGRCYP2D6 | |
| SCHEMBL9196432 | 0.84 | POLB (0.64) | CYP2C8CES2CES1LMNAALDH1A1 | |
| SCHEMBL4842051 | 0.82 | CYP2C8 (0.64) | CYP2C8CES2CES1LMNAALDH1A1 | |
| SCHEMBL5155346 | 0.82 | AKR1C2 (0.44) | CYP2C8ALDH1A1AKR1C2AKR1C1POLB | |
| SCHEMBL1787406 | 0.82 | MAPT (0.59) | LMNAALDH1A1CYP1A2PGRCYP2D6 | |
| SCHEMBL16108714 | 0.81 | AKR1C3 (0.43) | CYP2C8LMNAALDH1A1CYP1A2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572672-B1 | BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS | SOSEI R & D LTD (GB) | 2008-08-13 | — | — | EP | disclosed |
| EP-1950206-A1 | Benzoxazocines and their use as monoamine-reuptake inhibitors | Sosei R&D Ltd. (GB) | 2008-07-30 | — | — | EP | disclosed |
| US-20060019940-A1 | Novel benzoxazocines and their therapeutic use | SOSEI R&D LTD. (GB) | 2006-01-26 | — | — | US | disclosed |
| EP-1572672-A1 | BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS | Arakis Ltd. (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056788-A1 | BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS | ARAKIS LTD. (GB) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019940-A1 | Novel benzoxazocines and their therapeutic use | HTR4, OPRM1, GRM4 | CYP2C8 364/4885CES2 290/4885CES1 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.