Pyrimidine

Pyrimidine

SCHEMBL467971

O=S(=O)(O)Nc1ccccc1.c1c[nH]nn1.c1cncnc1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRB P23467 4/20 0.36
PTPN2 P17706 2/20 0.36
PTPN1 P18031 2/20 0.36
PTPRA P18433 1/20 0.36
KEAP1 Q14145 2/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
PKM P14618 4/20 0.33
ALDH1A1 P00352 3/20 0.33
ACP1 P24666 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
IL1RN P18510 1/20 0.33
ERAP1 Q9NZ08 1/20 0.33
USP2 O75604 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
NAMPT P43490 1/20 0.31
PTPRC P08575 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8558704 0.74 KEAP1 (0.42) KEAP1CA1CA2PKMALDH1A1
Pyrimidine SCHEMBL27313382 0.73
Pyrimidine SCHEMBL6831811 0.73
Benzene SCHEMBL6746153 0.73 CA2 (0.58) PTPRBPTPN2PTPN1PTPRAKEAP1
SCHEMBL146561 0.73 CA2 (0.58) PTPRBPTPN2PTPN1PTPRAKEAP1
Pyrimidine SCHEMBL27468324 0.73
Pyrimidine SCHEMBL474106 0.73
Pyrimidine SCHEMBL28340856 0.73
SCHEMBL17961207 0.72 TSHR (0.57) CA1CA2ALDH1A1SMN1; SMN2KDM4E
SCHEMBL28008413 0.72 KEAP1 (0.45) PTPRBPTPN2PTPN1PTPRAKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2385756-B1 SOYBEAN EVENT 127 AND METHODS RELATED THERETO BASF AGROCHEMICAL PRODUCTS BV (NL) 2019-04-10 EP disclosed
US-9961848-B2 Soybean event 127 and methods related thereto EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA-EMBRAPA (BR) 2018-05-08 US disclosed
EP-2134159-B1 AHAS MUTANTS BASF PLANT SCIENCE GMBH (DE) 2017-06-21 EP disclosed
US-20150299726-A1 AHAS MUTANTS BASF PLANT SCIENCE GMBH 2015-10-22 US disclosed
US-20150250129-A1 SOYBEAN EVENT 127 AND METHODS RELATED THERETO BASF AGROCHEMICAL PRODUCTS B.V. (NL) 2015-09-10 US disclosed
US-9024114-B2 Soybean event 127 and methods related thereto Empresa Brasileira de Pesquisa Agropecuaria—EMBRAPA (BR) 2015-05-05 US disclosed
EP-2574233-A1 AHAS mutants BASF Plant Science GmbH (DE) 2013-04-03 EP disclosed
EP-2570024-A1 AHAS mutants BASF Plant Science GmbH (DE) 2013-03-20 EP disclosed
EP-2561750-A1 AHAS mutants BASF Plant Science GmbH (DE) 2013-02-27 EP disclosed
EP-2561749-A1 AHAS mutants BASF Plant Science GmbH (DE) 2013-02-27 EP disclosed
US-20120117676-A1 Soybean Event 127 and Methods Related Thereto BASF AGROCHEMICAL PRODUCTS B.V. (NL) 2012-05-10 US disclosed
EP-2385756-A1 SOYBEAN EVENT 127 AND METHODS RELATED THERETO BASF Agrochemical Products, B.V. (NL) 2011-11-16 EP disclosed
US-8041483-B2 Exterior airbag deployment techniques AUTOMOTIVE TECHNOLOGIES INTERNATIONAL, INC. (US) 2011-10-18 US disclosed
US-20100287641-A1 AHAS MUTANTS BASF PLANT SCIENCE GMBH (DE) 2010-11-11 US disclosed
WO-2010080829-A1 SOYBEAN EVENT 127 AND METHODS RELATED THERETO BASF AGROCHEMICAL PRODUCTS B.V. (NL) 2010-07-15 WO disclosed
EP-2134159-A2 AHAS MUTANTS BASF Plant Science GmbH (DE) 2009-12-23 EP disclosed
WO-2008124495-A2 AHAS MUTANTS BASF PLANT SCIENCE GMBH (DE) 2008-10-16 WO disclosed
WO-2003044200-A1 NUCLEOTIDE SEQUENCE CODING FOR AN ENZYME HAVING ACETOLACTASE SYNTHASE ACTIVITY, PLANT CELL AND PLANT CONTAINING SAME, AND CROP WEEDING METHOD HOQUET, MICHEL (FR) 2003-05-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120117676-A1 Soybean Event 127 and Methods Related Thereto HAO1, HAAO, CYP2A7 PTPRB 1185/4885PTPN2 1203/4885PTPN1 545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.