Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 7/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.45 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679937 | 1.00 | ABCC9 (0.49) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL5220330 | 0.88 | ABCC9 (0.64) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL5220348 | 0.88 | ABCC9 (0.64) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL5216594 | 0.79 | CYP11B2 (0.47) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL4679942 | 0.79 | ABCC9 (0.46) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL5216587 | 0.79 | CYP11B2 (0.47) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL4683356 | 0.78 | ABCC9 (0.64) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL4683344 | 0.78 | ABCC9 (0.64) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL4678955 | 0.74 | KCNJ11 (0.71) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 | |
| SCHEMBL4678949 | 0.74 | KCNJ11 (0.71) | ABCC9KCNJ11CYP11B2ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2008-07-16 | — | — | EP | disclosed |