SCHEMBL4680337

SCHEMBL4680337

CCNC(C)Cc1ccc(F)cc1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 7/20 0.66
SLC6A4 P31645 7/20 0.62
LMNA P02545 2/20 0.50
MAPT P10636 1/20 0.50
ADRA2C P18825 1/20 0.50
HTR2A P28223 1/20 0.50
ADRA1A P35348 1/20 0.50
DRD3 P35462 1/20 0.50
OPRK1 P41145 1/20 0.50
HTR2B P41595 1/20 0.50
TRPA1 O75762 1/20 0.48
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
TSHR P16473 1/20 0.42
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10560323 0.98 SIGMAR1 (0.63) SIGMAR1SLC6A4LMNAMAPTADRA2C
SCHEMBL25918452 0.85 SIGMAR1 (0.68) SIGMAR1SLC6A4ADRA2CHTR2AADRA1A
SCHEMBL29432962 0.82 TRPA1 (0.47) SIGMAR1SLC6A4HTR2AADRA1ATRPA1
SCHEMBL10563230 0.82 SIGMAR1 (0.56) SIGMAR1
SCHEMBL19012043 0.82 SIGMAR1 (0.68) SIGMAR1SLC6A4LMNAMAPTADRA2C
Hydrochloric Acid SCHEMBL10560586 0.80 SIGMAR1 (0.55) SIGMAR1
SCHEMBL31545550 0.80 SIGMAR1 (0.66) SIGMAR1SLC6A4LMNAMAPTADRA2C
SCHEMBL22249109 0.80 SIGMAR1 (0.66) SIGMAR1SLC6A4LMNAMAPTADRA2C
SCHEMBL8441968 0.80 SIGMAR1 (0.66) SIGMAR1SLC6A4HTR2AADRA1ACYP3A4
SCHEMBL14521880 0.80 SIGMAR1 (0.66) SIGMAR1SLC6A4HTR2AADRA1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US disclosed
EP-1058680-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-12-13 EP disclosed
WO-1999043657-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1999-09-02 WO disclosed
US-4857553-A SIDE EFFECT REDUCTION A. H. ROBINS COMPANY, INCORPORATED (US) 1989-08-15 US disclosed
EP-0302757-A2 Anti-emetic serotonin depleting agents A.H. ROBINS COMPANY, INCORPORATED (US) 1989-02-08 EP disclosed