Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 12/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4531987 | 0.91 | TACR1 (0.56) | LMNAGLATSHRTACR1MC4R | |
| SCHEMBL4681339 | 0.87 | MC4R (0.47) | LMNAGLATSHRMC4RSMN1; SMN2 | |
| SCHEMBL4681379 | 0.82 | MC4R (0.49) | LMNAGLATSHRMC4R | |
| SCHEMBL4684460 | 0.82 | MC4R (0.55) | MC4R | |
| SCHEMBL4681340 | 0.81 | MC4R (0.51) | MC4R | |
| SCHEMBL4677982 | 0.81 | MC4R (0.43) | LMNAGLATSHRMC4R | |
| SCHEMBL4784715 | 0.80 | MC4R (0.45) | LMNAGLATSHRMC4R | |
| SCHEMBL6156128 | 0.80 | AKT1 (0.57) | LMNAGLATSHRTACR1MC4R | |
| SCHEMBL4504452 | 0.80 | AKT1 (0.57) | LMNAGLATSHRTACR1MC4R | |
| SCHEMBL4514596 | 0.80 | AKT1 (0.57) | LMNAGLATSHRTACR1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | disclosed |