Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 15/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4683042 | 0.91 | MAPT (0.46) | MC4RLMNATNKSTNKS2 | |
| SCHEMBL4677982 | 0.91 | MC4R (0.43) | MC4RLMNAGLATSHR | |
| SCHEMBL4681339 | 0.87 | MC4R (0.47) | MC4RCYP3A4MC5RMC3RAKT1 | |
| SCHEMBL4521185 | 0.86 | MC4R (0.40) | MC4R | |
| SCHEMBL4681085 | 0.80 | LMNA (0.47) | MC4RLMNAGLATSHR | |
| SCHEMBL4685109 | 0.79 | MC4R (0.42) | MC4RMC5RMC3RLMNAGLA | |
| SCHEMBL4681379 | 0.79 | MC4R (0.49) | MC4RLMNAGLATSHR | |
| SCHEMBL4681340 | 0.78 | MC4R (0.51) | MC4R | |
| SCHEMBL4532255 | 0.74 | MC4R (0.67) | MC4RMC5RMC3R | |
| SCHEMBL4532263 | 0.74 | MC4R (0.47) | MC4RMC5RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | disclosed |