Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348542 | 0.85 | ALDH1A1 (0.49) | OPRM1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL7615416 | 0.81 | MEN1 (0.58) | OPRM1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL11047233 | 0.80 | OPRM1 (0.52) | OPRM1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL21874377 | 0.79 | OPRM1 (0.72) | OPRM1SIGMAR1 | |
| SCHEMBL7617991 | 0.78 | ALDH1A1 (0.57) | SIGMAR1ALDH1A1MEN1KMT2APRCP | |
| SCHEMBL5641709 | 0.76 | OPRM1 (0.52) | OPRM1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL349225 | 0.75 | MEN1 (0.44) | OPRM1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL14408208 | 0.73 | ELANE (0.48) | ALDH1A1KMT2A | |
| SCHEMBL23485191 | 0.72 | OPRM1 (0.53) | OPRM1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL14258104 | 0.72 | OPRM1 (0.49) | OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045836-B1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1171113-B1 | COMPOUNDS USEFUL AS PHOSPHOTYROSINE MIMICS | BOEHRINGER INGELHEIM PHARMA (US) | 2004-06-02 | — | — | EP | disclosed |
| US-6284768-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| US-6268365-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-07-31 | — | — | US | disclosed |
| US-6156784-A | Compounds useful as phosphotyrosine mimics | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| EP-1045836-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-6054470-A | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999031066-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |