Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045094 | 0.92 | OPRM1 (0.54) | OPRM1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11050761 | 0.87 | OPRM1 (0.67) | OPRM1ALDH1A1 | |
| SCHEMBL4682851 | 0.80 | OPRM1 (0.58) | OPRM1ALDH1A1MEN1KMT2APRCP | |
| SCHEMBL11047897 | 0.79 | OPRM1 (0.47) | OPRM1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL348542 | 0.77 | ALDH1A1 (0.49) | OPRM1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL24220122 | 0.76 | OPRM1 (0.76) | OPRM1ALDH1A1 | |
| SCHEMBL7615416 | 0.76 | MEN1 (0.58) | OPRM1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11800383 | 0.76 | TSHR (0.39) | OPRM1MEN1KMT2A | |
| SCHEMBL11287102 | 0.74 | HSD11B1 (0.40) | OPRM1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18500642 | 0.73 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035902-B1 | 1-(4-ARYL-CYCLOHEXYL)PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-10-31 | — | — | EP | disclosed |
| US-4329353-A | ANTIEMETIC AND NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-05-11 | — | — | US | disclosed |
| EP-0035902-A1 | 1-(4-Aryl-cyclohexyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-09-16 | — | — | EP | disclosed |