SCHEMBL4683136

SCHEMBL4683136

CCN(CC1CCN(C(=O)OC(C)C)CC1)C(C)Cc1ccc(OC)cc1.O=C(O[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 2/20 0.42
MMP13 P45452 2/20 0.42
MMP3 P08254 1/20 0.42
MMP7 P09237 1/20 0.42
MMP9 P14780 1/20 0.42
MMP8 P22894 1/20 0.42
GPR119 Q8TDV5 3/20 0.39
LMNA P02545 3/20 0.38
RAB9A P51151 2/20 0.38
CYP3A4 P08684 2/20 0.38
CHRM3 P20309 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
CYP2D6 P10635 2/20 0.38
CHRM1 P11229 2/20 0.38
POLB P06746 1/20 0.38
ADRB2 P07550 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
DRD2 P14416 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4683292 0.92 LMNA (0.40) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
Water SCHEMBL7877668 0.91 LMNA (0.41) MMP1MMP13LMNARAB9ACYP3A4
Water SCHEMBL7873458 0.90 LMNA (0.39) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
SCHEMBL4683059 0.89 CYP2D6 (0.49) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
Water SCHEMBL4680443 0.89 LMNA (0.38) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
Water SCHEMBL4679971 0.89 LMNA (0.40) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
SCHEMBL4682768 0.89 ALDH1A1 (0.39) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
Water SCHEMBL4677879 0.89 YAP1 (0.44) MMP1MMP13MMP3MMP7MMP9
SCHEMBL4682363 0.89 CYP2D6 (0.41) LMNARAB9ACYP3A4CHRM3SMN1; SMN2
SCHEMBL8110652 0.88 YAP1 (0.37) LMNARAB9ACYP3A4CHRM3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US disclosed