SCHEMBL468358

SCHEMBL468358

C/C=C/C=C/C(=O)Oc1cccc2cccnc12

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.65
ALDH1A1 P00352 3/20 0.65
LMNA P02545 6/20 0.64
L3MBTL1 Q9Y468 5/20 0.64
NPSR1 Q6W5P4 4/20 0.64
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
HTT P42858 1/20 0.64
POLB P06746 3/20 0.59
MAPT P10636 3/20 0.59
TDP1 Q9NUW8 1/20 0.59
METAP2 P50579 1/20 0.53
METAP1 P53582 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
HSP90AA1 P07900 1/20 0.50
USP2 O75604 1/20 0.49
ALOX15 P16050 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
GAA P10253 1/20 0.47
PRSS1 P07477 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22444485 0.87 LMNA (0.76) KDM4EALDH1A1LMNAL3MBTL1NPSR1
SCHEMBL3454629 0.79 LMNA (0.61) KDM4EALDH1A1LMNAL3MBTL1NPSR1
SCHEMBL4205753 0.79 LMNA (0.64) KDM4EALDH1A1LMNAL3MBTL1NPSR1
SCHEMBL10751795 0.78 LMNA (1.00) KDM4EALDH1A1LMNAL3MBTL1NPSR1
Butanedione SCHEMBL5530736 0.78 LMNA (0.63) KDM4EALDH1A1LMNAL3MBTL1NPSR1
SCHEMBL20788563 0.77 ALDH1A1 (0.53) KDM4EALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL250301 0.76 LMNA (0.65) KDM4EALDH1A1LMNAL3MBTL1NPSR1
SCHEMBL28459061 0.76 LMNA (0.69) KDM4EALDH1A1LMNAL3MBTL1NPSR1
Hydrochloric Acid SCHEMBL2563239 0.75 LMNA (0.63) KDM4EALDH1A1LMNAL3MBTL1NPSR1
SCHEMBL3415803 0.75 LMNA (0.71) KDM4EALDH1A1LMNAL3MBTL1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006023-A1 SORBIC ACID AND DERIVATIVES THEREOF TO ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (US) 2016-04-13 EP claimed
US-20150099015-A1 Sorbic and Benzoic Acid and Derivatives Thereof Enhance the Activity of a Neuropharmaceutical LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER 2015-04-09 US claimed
CN-102292094-B Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical LOS ANGELES BIOMED RES INST 2013-08-14 CN claimed
CN-102292094-A Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical 2011-12-21 CN claimed
EP-2389187-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (US) 2011-11-30 EP claimed
US-8040867-B2 Method of multi-antenna wireless data emission, emitter and receiver using the method MITSUBISHI ELECTRIC CORPORATION (JP) 2011-10-18 US claimed
WO-2010085452-A9 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR - UCLA MEDICAL CENTER (US) 2011-01-06 WO claimed
US-20100189818-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2010-07-29 US claimed
WO-2010085452-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR - UCLA MEDICAL CENTER (US) 2010-07-29 WO claimed
US-11529342-B2 Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2022-12-20 US disclosed
EP-3006023-B1 SORBIC ACID AND DERIVATIVES THEREOF TO ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RES INST HARBOR UCLA MEDICAL CT (US) 2019-06-26 EP disclosed
US-20190151301-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2019-05-23 US disclosed
EP-3006024-B1 BENZOIC ACID OR SALTS THEREOF TO ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RES INST HARBOR UCLA MEDICAL CT (US) 2019-03-20 EP disclosed
US-10149845-B2 Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2018-12-11 US disclosed
CN-102292094-A Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical 2011-12-21 CN disclosed
EP-2389187-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (US) 2011-11-30 EP disclosed
US-8040867-B2 Method of multi-antenna wireless data emission, emitter and receiver using the method MITSUBISHI ELECTRIC CORPORATION (JP) 2011-10-18 US disclosed
WO-2010085452-A9 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR - UCLA MEDICAL CENTER (US) 2011-01-06 WO disclosed
US-20100189818-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2010-07-29 US disclosed
WO-2010085452-A1 SORBIC AND BENZOIC ACID AND DERIVATIVES THEREOF ENHANCE THE ACTIVITY OF A NEUROPHARMACEUTICAL LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR - UCLA MEDICAL CENTER (US) 2010-07-29 WO disclosed