Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14077653 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL4740641 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL14077643 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL3890906 | 0.74 | SMN1; SMN2 (0.62) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL14161063 | 0.74 | MAPK14 (0.43) | RAB9AKMT2APOLBLCKMAPK14 | |
| SCHEMBL4680753 | 0.74 | MAPK14 (0.46) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL20332878 | 0.73 | SMN1; SMN2 (0.55) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL1233320 | 0.72 | RAB9A (0.65) | SMN1; SMN2GAAKDM4ETSHRALDH1A1 | |
| SCHEMBL14077639 | 0.71 | HDAC1 (0.44) | TSHRALDH1A1L3MBTL1HPGD | |
| SCHEMBL28321600 | 0.70 | SMN1; SMN2 (0.70) | SMN1; SMN2KDM4ETSHRL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214623-A1 | N-(2,2-Dimethylpropyl)-6- -3-Pyridinecarboxamide | CHANDI AMRIK | 2008-09-04 | — | — | US | disclosed |
| US-20080214623-A1 | N-(2,2-Dimethylpropyl)-6- -3-Pyridinecarboxamide | CHANDI AMRIK | 2008-09-04 | — | — | US | disclosed |
| US-20080214623-A1 | N-(2,2-Dimethylpropyl)-6- -3-Pyridinecarboxamide | CHANDI AMRIK | 2008-09-04 | — | — | US | disclosed |
| EP-1891061-A1 | N-(2, 2-DIMETHYLPROPYL) -6- (3-FLUORO-5- ( (3-ISOXAZOLYLAMINO) CARBONYL) -2-METHYLPHENY L) -3-PYRIDINECARBOXAMIDE | SmithKline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006134382-A1 | N-(2, 2-DIMETHYLPROPYL) -6- (3-FLUORO-5- ( (3-ISOXAZOLYLAMINO) CARBONYL) -2-METHYLPHENY L) -3-PYRIDINECARBOXAMIDE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214623-A1 | N-(2,2-Dimethylpropyl)-6- -3-Pyridinecarboxamide | MAPKAPK2, MAP3K2, MAP4K2 | SMN1; SMN2 741/4885GAA 3239/4885KDM4E 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.