Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.46 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681674 | 0.85 | MAPK14 (0.66) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL4739276 | 0.79 | MAPK14 (0.46) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL14077653 | 0.79 | SMN1; SMN2 (0.56) | MAPK14CYP2C9SMN1; SMN2KDM4ELCK | |
| SCHEMBL4684237 | 0.78 | SMN1; SMN2 (0.39) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL4685562 | 0.78 | MAPK14 (0.51) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL14403123 | 0.76 | P4HA1 (0.49) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL4740641 | 0.75 | SMN1; SMN2 (0.54) | MAPK14CYP2C9SMN1; SMN2KDM4ELCK | |
| SCHEMBL4684166 | 0.74 | SMN1; SMN2 (0.53) | MAPK14CYP2C9SMN1; SMN2KDM4ELCK | |
| SCHEMBL3409067 | 0.70 | MAPK14 (0.82) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL13337984 | 0.69 | MAPK14 (0.60) | MAPK14CYP2C9MAPK11BUB1PRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891061-A1 | N-(2, 2-DIMETHYLPROPYL) -6- (3-FLUORO-5- ( (3-ISOXAZOLYLAMINO) CARBONYL) -2-METHYLPHENY L) -3-PYRIDINECARBOXAMIDE | SmithKline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006134382-A1 | N-(2, 2-DIMETHYLPROPYL) -6- (3-FLUORO-5- ( (3-ISOXAZOLYLAMINO) CARBONYL) -2-METHYLPHENY L) -3-PYRIDINECARBOXAMIDE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-21 | — | — | WO | disclosed |