Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685977 | 0.80 | THRA (0.46) | THRBTHRAKCNA3MEN1KMT2A | |
| SCHEMBL30468864 | 0.80 | THRA (0.46) | THRBTHRAKCNA3MEN1KMT2A | |
| SCHEMBL6876891 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KCNA3PTPN1HPGDPDE4D | |
| SCHEMBL10247054 | 0.79 | PTPN1 (0.55) | ALDH1A1PTPN1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL3799664 | 0.78 | AGXT (0.44) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4687273 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KCNA3PTPN1HPGDSMN1; SMN2 | |
| SCHEMBL19755566 | 0.76 | ALDH1A1 (0.48) | ALDH1A1PTPN1MEN1KMT2ALMNA | |
| SCHEMBL4681950 | 0.76 | L3MBTL1 (0.42) | ALDH1A1THRBTHRAMEN1KMT2A | |
| SCHEMBL19625790 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KCNA3PTPN1LMNAHPGD | |
| SCHEMBL83012 | 0.75 | ALDH1A1 (0.47) | ALDH1A1PTPN1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973906-A1 | HYDROXYDIHYDROPYRIDOPY RAZINE-1,8-DIONES AND METHODS FOR INHIBITING HIV INTEGRASE | Virochem Pharma Inc. (CA) | 2008-10-01 | — | — | EP | disclosed |
| WO-2006066414-A1 | HYDROXYDIHYDROPYRIDOPY RAZINE-1,8-DIONES AND METHODS FOR INHIBITING HIV INTEGRASE | VIROCHEM PHARMA INC. (CA) | 2006-06-29 | — | — | WO | disclosed |