Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.66 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.66 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | PPM1D | O15297 | 2/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.47 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264931 | 0.87 | CYP4F2 (0.54) | CYP4F2CYP4A11LOXL2PPM1DSLC7A5 | |
| SCHEMBL23642786 | 0.86 | CYP4F2 (0.63) | CYP4F2CYP4A11LOXL2PPM1DSLC7A5 | |
| SCHEMBL2197290 | 0.85 | CYP4F2 (0.61) | CYP4F2CYP4A11LOXL2PPM1DSLC7A5 | |
| SCHEMBL757429 | 0.85 | LOXL2 (0.62) | CYP4F2CYP4A11LOXL2PPM1DSLC7A5 | |
| SCHEMBL70173 | 0.84 | CYP4F2 (0.83) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL1532753 | 0.83 | KDM4E (0.55) | CYP4F2CYP4A11LOXL2PPM1DKDM4E | |
| SCHEMBL27722715 | 0.83 | CYP4F2 (0.50) | CYP4F2CYP4A11PPM1D | |
| SCHEMBL28284087 | 0.80 | PARP14 (0.51) | PARP1MAP1LC3BMAP1LC3A | |
| SCHEMBL17982797 | 0.80 | LOXL2 (0.56) | CYP4F2CYP4A11LOXL2PPM1DSLC7A5 | |
| SCHEMBL46931 | 0.80 | CYP4A11 (1.00) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910364-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007011833-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | disclosed |