Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682179 | 0.79 | RAB9A (0.48) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL4095279 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL4678382 | 0.73 | MEN1 (0.49) | SMN1; SMN2MAPTKMT2AMEN1HTT | |
| Hydrochloric Acid SCHEMBL16702112 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL6614404 | 0.73 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL11880613 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL3632175 | 0.72 | CES2 (0.46) | SMN1; SMN2POLBHTTLMNAL3MBTL1 | |
| SCHEMBL4095276 | 0.72 | POLB (0.44) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL4678014 | 0.72 | EGFR (0.33) | KMT2AALDH1A1LMNAP2RX7CA9 | |
| SCHEMBL10384266 | 0.71 | MEN1 (0.54) | SMN1; SMN2MAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1198456-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2007-09-19 | — | — | EP | disclosed |