Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685495 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL6641958 | 0.70 | SLC6A9 (0.30) | — | |
| SCHEMBL11880613 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL4685493 | 0.66 | ALDH1A1 (0.39) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL11196325 | 0.66 | POLB (0.55) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL4685491 | 0.66 | ALDH1A1 (0.39) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL4095279 | 0.65 | SMN1; SMN2 (0.40) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL15577575 | 0.64 | SMN1; SMN2 (0.57) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| Hydrochloric Acid SCHEMBL16702112 | 0.64 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTKMT2APOLBMAPT | |
| SCHEMBL6613001 | 0.63 | MEN1 (0.46) | SMN1; SMN2HTTKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |