Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678368 | 0.85 | HTT (0.53) | SMN1; SMN2MEN1KMT2ACA2ALDH1A1 | |
| SCHEMBL4681864 | 0.85 | CA2 (0.54) | SMN1; SMN2HPGDCA2ALDH1A1RAB9A | |
| SCHEMBL15260867 | 0.85 | CA2 (0.66) | SMN1; SMN2MEN1KMT2AHPGDCA2 | |
| SCHEMBL76893 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AHPGDCA2 | |
| SCHEMBL76588 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AHPGDCA2 | |
| SCHEMBL4679702 | 0.78 | HPGDS (0.59) | SMN1; SMN2MEN1KMT2AHPGDCA2 | |
| Hydrochloric Acid SCHEMBL4685394 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AHPGDCA2 | |
| SCHEMBL10761872 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL4682300 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4682849 | 0.74 | CNR2 (0.50) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1198456-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2007-09-19 | — | — | EP | disclosed |
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |
| EP-1198456-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001009096-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-02-08 | — | — | WO | disclosed |