Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 15/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4683230 | 0.92 | CCR5 (0.75) | CCR5OPRM1OPRL1 | |
| SCHEMBL4679294 | 0.91 | CCR5 (0.68) | CCR5OPRM1OPRL1PLD2PLD1 | |
| SCHEMBL14144431 | 0.89 | CCR5 (0.51) | CCR5OPRM1OPRL1PLD2PLD1 | |
| SCHEMBL6170250 | 0.89 | CCR5 (0.63) | CCR5OPRM1OPRL1 | |
| SCHEMBL13544013 | 0.88 | CCR5 (0.66) | CCR5OPRM1OPRL1PLD2PLD1 | |
| SCHEMBL4682434 | 0.87 | CCR5 (0.85) | CCR5OPRM1OPRL1 | |
| SCHEMBL14415521 | 0.87 | CCR5 (0.65) | CCR5 | |
| SCHEMBL5511844 | 0.86 | CCR5 (0.85) | CCR5 | |
| SCHEMBL13544010 | 0.84 | CCR5 (0.78) | CCR5OPRM1OPRL1 | |
| SCHEMBL13544009 | 0.83 | CCR5 (0.85) | CCR5OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569933-B1 | PYRROLIDINE AND AZETIDINE COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-23 | — | — | EP | disclosed |
| US-7271172-B2 | Pyrrolidine and azetidine compounds as CCR5 antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271172-B2 | Pyrrolidine and azetidine compounds as CCR5 antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271172-B2 | Pyrrolidine and azetidine compounds as CCR5 antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1569933-A1 | PYRROLIDINE AND AZETIDINE COMPOUNDS AS CCR5 ANTAGONISTS | SmithKline Beecham Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004055016-A1 | PYRROLIDINE AND AZETIDINE COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |