Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 6/20 | 0.62 |
| ▸ | FLT3 | P36888 | 5/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686832 | 0.85 | PTK2 (0.68) | PAK1FLT3PTK2RAB9AMAPK1 | |
| SCHEMBL4693022 | 0.82 | FLT3 (0.66) | FLT3MAPK1HTTMKNK1 | |
| SCHEMBL6774600 | 0.81 | KDM4E (0.50) | PAK1RAB9AMAPTMAPK1HTT | |
| SCHEMBL4691855 | 0.80 | MKNK1 (0.67) | PAK1FLT3MAPK1MKNK1BRAF | |
| SCHEMBL4686972 | 0.79 | HTT (0.48) | PAK1RAB9AMAPTMAPK1HTT | |
| SCHEMBL4686916 | 0.78 | PAK1 (0.64) | PAK1FLT3RAB9AMAPTMAPK1 | |
| SCHEMBL6774592 | 0.77 | MAPT (0.51) | PAK1RAB9AMAPTMAPK1HTT | |
| SCHEMBL3297013 | 0.76 | HTT (0.50) | RAB9AMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL3297016 | 0.75 | BRD4 (0.60) | RAB9AHTTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL4690820 | 0.75 | LMNA (0.66) | FLT3PTK2MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |