Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686842 | 0.86 | SLC29A1 (0.61) | LMNASLC29A1ROCK2ROCK1MAPK1 | |
| SCHEMBL4693022 | 0.82 | FLT3 (0.66) | LMNASLC29A1ROCK2ROCK1MAPK1 | |
| SCHEMBL14559577 | 0.80 | ALDH1A1 (0.55) | LMNASLC29A1MAPK1FLT3CYP1A2 | |
| SCHEMBL4690818 | 0.79 | ADORA3 (0.48) | LMNAROCK2ROCK1MAPK1CYP1A2 | |
| SCHEMBL2343403 | 0.78 | MAPK1 (0.58) | LMNASLC29A1MAPK1FLT3PTK2 | |
| SCHEMBL4686975 | 0.75 | PAK1 (0.62) | MAPK1FLT3PTK2KDM4E | |
| SCHEMBL4686832 | 0.75 | PTK2 (0.68) | LMNAMAPK1FLT3POLBPTK2 | |
| SCHEMBL14559625 | 0.73 | CYP1A2 (0.51) | SLC29A1MAPK1FLT3CYP1A2POLB | |
| SCHEMBL19646931 | 0.73 | TTBK1 (0.62) | LMNAMAPK1FLT3CYP1A2 | |
| SCHEMBL5078942 | 0.73 | CFD (0.56) | ROCK2ROCK1ADORA3NPSR1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1360582-A | Quinazoline derivs. | ASTRAZENECA UK LTD (GB) | 2002-07-24 | — | — | CN | claimed |
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |
| CN-1360582-A | Quinazoline derivs. | ASTRAZENECA UK LTD (GB) | 2002-07-24 | — | — | CN | disclosed |
| WO-2002002534-A1 | QUINAZOLINES WITH THERAPEUTIC USE | ASTRAZENECA AB (SE) | 2002-01-10 | — | — | WO | disclosed |