Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686975 | 0.77 | PAK1 (0.62) | MAPTRAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL10458447 | 0.74 | KDM4E (0.72) | MAPTRAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL5017650 | 0.73 | NPC1 (0.55) | MAPTRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8173925 | 0.71 | CYP1A2 (0.58) | RAB9AKDM4ENPC1CYP1A2ALOX15 | |
| SCHEMBL31412961 | 0.70 | ROCK2 (0.47) | KDM4EPOLBCYP1A2GAA | |
| SCHEMBL5015389 | 0.70 | DEGS1 (0.48) | RAB9AMEN1KMT2ANPC1POLB | |
| SCHEMBL10540658 | 0.70 | MEN1 (0.61) | MAPTRAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL5013515 | 0.68 | CCNE1 (0.50) | MAPTRAB9AMEN1KMT2APOLB | |
| SCHEMBL5014078 | 0.68 | SMN1; SMN2 (0.57) | MAPTRAB9AHTTSMN1; SMN2KMT2A | |
| SCHEMBL5015439 | 0.68 | TSHR (0.56) | MAPTRAB9AHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |