Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685029 | 0.79 | CHRM2 (0.37) | DPP4ALDH1A1CYP2D6CHRM2CHRM4 | |
| SCHEMBL4681145 | 0.75 | HTT (0.41) | ALDH1A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5899795 | 0.74 | CHRM2 (0.36) | DPP4ALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL4681766 | 0.73 | HTT (0.43) | ALDH1A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2991774 | 0.73 | HTT (0.43) | ALDH1A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2618406 | 0.69 | NPC1 (0.40) | DPP4ALDH1A1CYP2D6KMT2ANPC1 | |
| SCHEMBL19770247 | 0.67 | SCN9A (0.37) | ALDH1A1KMT2ANPC1RAB9ASCN9A | |
| SCHEMBL19770249 | 0.67 | SCN9A (0.37) | ALDH1A1KMT2ANPC1RAB9ASCN9A | |
| SCHEMBL4670206 | 0.66 | PKM (0.39) | DPP4ALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL26619641 | 0.65 | SLC18A3 (0.41) | ALDH1A1CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605756-A4 | PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE BY REDUCTIVE AMINATION OF LEVULINIC ACID ESTERS WITH ARYL AND ALKYL AMINES | DU PONT (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7129362-B2 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1605756-A2 | PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE BY REDUCTIVE AMINATION OF LEVULINIC ACID ESTERS WITH ARYL AND ALKYL AMINES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20050137406-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | E. I. DU PONT DE NEMOURS AND COMPANY | 2005-06-23 | — | — | US | disclosed |
| US-20050038265-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | MANZER LEO ERNEST (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050033062-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | MANZER LEO ERNEST (US) | 2005-02-10 | — | — | US | disclosed |
| US-20050033063-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | MANZER LEO ERNEST (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004085348-A2 | PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-10-07 | — | — | WO | disclosed |
| US-20040192938-A1 | Production of 5-mehyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033063-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | DPP4 2522/4885ALDH1A1 203/4885CYP2D6 192/4885 |
| US-20050137406-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | DPP4 2626/4885ALDH1A1 227/4885CYP2D6 126/4885 |
| US-20040192938-A1 | Production of 5-mehyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | PAH, ALDH18A1, PNPO | DPP4 2210/4885ALDH1A1 213/4885CYP2D6 168/4885 |
| US-20050038265-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | DPP4 2522/4885ALDH1A1 203/4885CYP2D6 192/4885 |
| US-20050033062-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | DPP4 2522/4885ALDH1A1 203/4885CYP2D6 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.