Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681766 | 1.00 | HTT (0.43) | HTTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4681145 | 0.98 | HTT (0.41) | HTTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4670206 | 0.83 | PKM (0.39) | HTTALDH1A1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL11229667 | 0.81 | LMNA (0.41) | KMT2AGSK3AGSK3BLMNAPOLB | |
| SCHEMBL17001786 | 0.80 | PLG (0.34) | KMT2ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17001769 | 0.80 | PLG (0.34) | KMT2ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17001874 | 0.80 | CHRM2 (0.36) | ALDH1A1KMT2AL3MBTL1SMN1; SMN2CHRM2 | |
| SCHEMBL18444558 | 0.80 | PLG (0.34) | KMT2ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17001872 | 0.80 | CHRM2 (0.36) | ALDH1A1KMT2AL3MBTL1SMN1; SMN2CHRM2 | |
| SCHEMBL4685029 | 0.78 | CHRM2 (0.37) | HTTALDH1A1KMT2ACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948506-A | THIN FILMS; COATINGS, MEMBRANE ELECTRODES; ABSORBERS; COMPLEXING AND REVERSE; BIOCOMPATIBILITY; OPTICAL FILTERS; DRUG DELIVERY | BEND RESEARCH, INC. (US) | 1990-08-14 | — | — | US | claimed |
| US-20240051974-A1 | DIRECT REDUCTIVE AMINATIONS WITH MONOTRIFLUOROACETOXY BORANE-AMINES | PURDUE RESEARCH FOUNDATION (US) | 2024-02-15 | — | — | US | disclosed |
| CN-110294701-B | Synthetic method of 5-methyl-2-pyrrolidone or derivatives thereof | 厦门大学 | 2021-07-09 | — | — | CN | disclosed |
| CN-110294701-A | A kind of synthetic method of 5- N-methyl-2-2-pyrrolidone N or derivatives thereof | 厦门大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-106699628-A | Method for preparing pyrrolidone by using levulinic acid | 合肥利夫生物科技有限公司 | 2017-05-24 | — | — | CN | disclosed |
| US-20100184764-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2010-07-22 | — | — | US | disclosed |
| US-7713979-B2 | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2010-05-11 | — | — | US | disclosed |
| US-7612216-B2 | Utilizing metal catalyst; one step; low cost | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-11-03 | — | — | US | disclosed |
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20080275043-A1 | Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 | ELI LILLY AND COMPANY | 2008-11-06 | — | — | US | disclosed |
| WO-2004015042-A2 | REFRIGERANT COMPOSITIONS COMPRISING PERFORMANCE ENHANCING ADDITIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |
| WO-2003104364-A1 | FLUOROCARBON, OXYGENATED AND NON-OXYGENATED LUBRICANT, AND COMPATIBILIZER COMPOSITION, AND METHOD FOR REPLACING REFRIGERATION COMPOSITION IN A REFRIGERATION SYSTEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-12-18 | — | — | WO | disclosed |
| US-20030209688-A1 | Refrigerant compositions containing a compatibilizer | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-11-13 | — | — | US | disclosed |
| WO-2003050200-A1 | REFRIGERANT COMPOSITIONS CONTAINING A COMPATIBILIZER AND USE THEROF IN A COMPRESSION REFRIGERATION APPARATUS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |
| EP-0273724-B1 | ACID GAS SCRUBBING BY COMPOSITE SOLVENT-SWOLLEN MEMBRANES | BEND RESEARCH, INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4948506-A | THIN FILMS; COATINGS, MEMBRANE ELECTRODES; ABSORBERS; COMPLEXING AND REVERSE; BIOCOMPATIBILITY; OPTICAL FILTERS; DRUG DELIVERY | BEND RESEARCH, INC. (US) | 1990-08-14 | — | — | US | disclosed |
| EP-0336535-A1 | Gas separation by composite solvent-swollen membranes | BEND RESEARCH, INC. (US) | 1989-10-11 | — | — | EP | disclosed |
| US-4824443-A | HIGHLY POLAR SOLVENT | BEND RESEARCH, INC. (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0273724-A2 | Acid gas scrubbing by composite solvent-swollen membranes | BEND RESEARCH, INC. (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4737166-A | SEPARATION OF HYDROGEN SULFIDE AND CARBON DIOXIDE FROM HYDROGEN, CARBON MONOXIDE AND HYDROCARBON GASES; SUPPORTED POLYMER | BEND RESEARCH, INC. (US) | 1988-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275043-A1 | Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSDL2, HSD17B1 | HTT 4629/4885ALDH1A1 108/4885CYP3A4 374/4885 |
| US-20100184764-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD17B1, HSD3B1 | HTT 4061/4885ALDH1A1 118/4885CYP3A4 436/4885 |
| US-20240051974-A1 | DIRECT REDUCTIVE AMINATIONS WITH MONOTRIFLUOROACETOXY BORANE-AMINES | MAOB, BCAT2, AADAT | HTT 3462/4885ALDH1A1 609/4885CYP3A4 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.