Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663667 | 0.92 | ALDH1A1 (0.60) | ALDH1A1RECQLAPPLTA4HNR1I2 | |
| SCHEMBL274829 | 0.89 | ALDH1A1 (0.62) | ALDH1A1RECQLCYP19A1APPLTA4H | |
| SCHEMBL14004242 | 0.88 | ALDH1A1 (0.56) | ALDH1A1RECQLNR1I2POLBGAA | |
| SCHEMBL2924048 | 0.85 | ALDH1A1 (0.58) | ALDH1A1RECQLCYP19A1APPLTA4H | |
| Propane SCHEMBL11670801 | 0.83 | LTA4H (0.62) | ALDH1A1RECQLCYP19A1APPLTA4H | |
| Propane SCHEMBL8652904 | 0.83 | LTA4H (0.62) | ALDH1A1RECQLCYP19A1APPLTA4H | |
| SCHEMBL20128986 | 0.82 | APP (0.59) | ALDH1A1RECQLAPPPOLBCYP3A4 | |
| SCHEMBL1412728 | 0.82 | APP (0.64) | ALDH1A1RECQLCYP19A1APPLTA4H | |
| SCHEMBL21876548 | 0.82 | APP (0.59) | ALDH1A1RECQLAPPPOLBCYP3A4 | |
| SCHEMBL1815639 | 0.82 | APP (0.64) | ALDH1A1RECQLCYP19A1APPLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981847-A1 | SECONDARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007088514-A1 | SECONDARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-09 | — | — | WO | disclosed |