Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.38 |
| ▸ | CCR3 | P51677 | 7/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003097 | 0.94 | GRIN2B (0.43) | TRPV1GRIN2BIDH1CHRM2CHRM1 | |
| SCHEMBL2009642 | 0.90 | TRPV1 (0.46) | TRPV1CNR1CHRM2CHRM1CHRM4 | |
| SCHEMBL2007919 | 0.81 | CNR1 (0.48) | TRPV1CNR1CHRM2CHRM1CHRM4 | |
| SCHEMBL12569103 | 0.81 | FAAH (0.54) | GRIN2BCNR1 | |
| SCHEMBL2003885 | 0.81 | ROCK2 (0.42) | TRPV1IDH1CNR1CHRM2CHRM1 | |
| SCHEMBL8236761 | 0.79 | FAAH (0.44) | TRPV1IDH1CNR1CHRM2CHRM1 | |
| SCHEMBL2010158 | 0.79 | ALDH1A1 (0.48) | TRPV1IDH1CNR1 | |
| SCHEMBL2009517 | 0.78 | PI4KB (0.43) | TRPV1IDH1LIMK2 | |
| SCHEMBL2010161 | 0.77 | CYP2C9 (0.45) | TRPV1IDH1 | |
| SCHEMBL2008277 | 0.77 | CHRM4 (0.41) | TRPV1CHRM2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |