Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744859 | 0.81 | KDR (0.35) | GBA1NOTUMCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL3339496 | 0.78 | GBA1 (0.49) | GBA1NOTUMALDH1A1PTGES2SCN5A | |
| SCHEMBL4741748 | 0.76 | CYP11B1 (0.34) | CYP11B1CYP11B2ALOX15PTGES2TRPM5 | |
| SCHEMBL3337670 | 0.68 | GBA1 (0.54) | GBA1ALDH1A1CYP3A4CYP2D6PTGES2 | |
| SCHEMBL3339265 | 0.68 | HTR6 (0.51) | GBA1CYP3A4CYP2D6PTGES2 | |
| SCHEMBL30643702 | 0.66 | DDB1 (0.52) | CYP1A2CYP3A4CYP2D6ADRB2ADRB1 | |
| SCHEMBL2710143 | 0.66 | DDB1 (0.52) | CYP1A2CYP3A4CYP2D6ADRB2ADRB1 | |
| SCHEMBL3644217 | 0.64 | HTR6 (0.62) | — | |
| SCHEMBL5095027 | 0.62 | KHK (0.45) | GBA1NOTUMALDH1A1PTGES2HTT | |
| SCHEMBL18903778 | 0.61 | CYP11B1 (0.39) | NOTUMCYP11B1CYP11B2ALDH1A1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984351-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007098418-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-08-30 | — | — | WO | disclosed |