Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 7/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687638 | 0.81 | GBA1 (0.36) | TRPM5NOTUMCYP11B1CYP11B2ADRB1 | |
| SCHEMBL3339265 | 0.77 | HTR6 (0.51) | PTGES2HTR6GBA1CYP2D6 | |
| SCHEMBL3644217 | 0.69 | HTR6 (0.62) | HTR6HTR1AHTR2A | |
| SCHEMBL3339496 | 0.68 | GBA1 (0.49) | NOTUMPTGES2HTR6SCN5ASCN9A | |
| SCHEMBL22753608 | 0.67 | HTR6 (0.63) | ADRB1HTR6HTR3EHTR3BHTR3A | |
| SCHEMBL4741748 | 0.66 | CYP11B1 (0.34) | TRPM5CYP11B1CYP11B2PTGES2HTR6 | |
| SCHEMBL3622199 | 0.65 | HTR6 (0.43) | PTGES2HTR6SCN5ASCN9AGBA1 | |
| SCHEMBL3640843 | 0.64 | HTR6 (0.63) | HTR6HTR1AHTR2A | |
| SCHEMBL22753668 | 0.60 | HTR6 (0.62) | ADRB1HTR6HTR3EHTR3BHTR3A | |
| SCHEMBL12107337 | 0.60 | AR (0.42) | NOTUMCYP11B1CYP11B2ADRB1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984351-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007098418-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-08-30 | — | — | WO | disclosed |