Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 5/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343929 | 0.79 | GBA1 (0.42) | HTR6PTGES2LMNASCN9ASCN5A | |
| SCHEMBL4687638 | 0.76 | GBA1 (0.36) | CYP11B1CYP11B2PTGES2ALOX15TRPM5 | |
| SCHEMBL4744859 | 0.66 | KDR (0.35) | CYP11B1CYP11B2HTR6PTGES2KDM4E | |
| SCHEMBL3342990 | 0.66 | KMT2A (0.45) | POLB | |
| SCHEMBL3335906 | 0.63 | HTR6 (0.50) | CYP11B1CYP11B2HTR6PTGES2HTR1A | |
| SCHEMBL3366957 | 0.63 | HTR6 (0.50) | HTR6PTGES2HTR1ASCN9ASCN5A | |
| SCHEMBL3339338 | 0.62 | PKM (0.49) | HTR6POLB | |
| SCHEMBL3338517 | 0.62 | HTR6 (0.51) | HTR6PTGES2SCN9ASCN5A | |
| SCHEMBL3338773 | 0.61 | HTR6 (0.52) | HTR6PTGES2SCN9ASCN5A | |
| SCHEMBL3336900 | 0.61 | HTR6 (0.60) | HTR6SLC6A4SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984351-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007098418-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-08-30 | — | — | WO | disclosed |