SCHEMBL4687933

SCHEMBL4687933

CNC(=O)c1ccc(-c2cc(C(F)(F)F)cc(S(=O)(=O)NC(CO)Cc3c[nH]c4ccccc34)c2)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
MMP7 P09237 1/20 0.47
NEK1 Q96PY6 2/20 0.46
NR3C1 P04150 8/20 0.44
MCL1 Q07820 1/20 0.44
POLB P06746 1/20 0.43
MMP2 P08253 4/20 0.43
MMP9 P14780 4/20 0.43
PGR P06401 2/20 0.42
NR3C2 P08235 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4646409 1.00 MEN1 (0.47) MEN1KMT2AMMP7NEK1NR3C1
SCHEMBL4647372 0.91 MEN1 (0.48) MEN1KMT2AMMP7NEK1NR3C1
SCHEMBL4648410 0.88 NEK1 (0.56) MEN1KMT2AMMP7NEK1NR3C1
SCHEMBL14025310 0.85 MEN1 (0.43) MEN1KMT2AMMP7NEK1NR3C1
SCHEMBL4648789 0.82 NR3C1 (0.49) MEN1KMT2ANEK1NR3C1POLB
SCHEMBL4647690 0.82 NR3C1 (0.47) MEN1KMT2ANEK1NR3C1POLB
SCHEMBL4685322 0.82 NR3C1 (0.47) MEN1KMT2ANEK1NR3C1POLB
SCHEMBL4646109 0.81 NR3C1 (0.47) MEN1KMT2ANEK1NR3C1POLB
SCHEMBL4645638 0.79 NR3C1 (0.42) MEN1KMT2ANEK1NR3C1POLB
SCHEMBL14025315 0.79 NEK1 (0.55) MEN1KMT2AMMP7NEK1NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1964834-A1 Sulphonyltryptophanols Bayer Schering Pharma Aktiengesellschaft (DE) 2008-09-03 EP disclosed