Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31530471 | 0.81 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL711351 | 0.80 | GAA (0.52) | RAB9ASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL4488971 | 0.78 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL4688813 | 0.77 | ALDH1A1 (0.44) | TP53MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2821798 | 0.77 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL2821802 | 0.77 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL11394788 | 0.76 | GAA (0.47) | RAB9AMAPTHTTALDH1A1MAPK1 | |
| SCHEMBL8226861 | 0.76 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL8226815 | 0.75 | MAPT (0.50) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL13302673 | 0.75 | TAS1R3 (0.63) | RAB9ANPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |